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Therefore, Avandia should not be used in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis. patients taking Avandia, the public health impact could be substantial, the authors point out. "Across the extensive dataset for Avandia, GlaxoSmithKline believes there is no consistent or systematic evidence that Avandia increases the risk of heart attack or cardiovascular death in comparison to other anti-diabetic medicines," the company said in a prepared statement. Glucovance can also be combined with other diabetes drugs such as Avandia. Actos should probably be the first-line choice, over Avandia, he said. "One in 30 patients taking rosiglitazone (Avandia) over a year will have heart failure, that's very substantial.
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